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Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B.

Authors
Pandey-JP; Kistner-Griffin-E; Radwan-FF; Kaur-N; Namboodiri-AM; Black-L; Butler-MA; Carreon-T; Ruder-AM
Source
J Infect Dis 2014 Dec; 210(11):1823-1826
NIOSHTIC No.
20044710
Abstract
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (y marker) genotypes: Anti-HCMV gB antibody levels were the highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and the lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 ug/mL, respectively; p=0.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
Keywords
Humans; Men; Women; Risk-factors; Viral-diseases; Viral-infections; Exposure-levels; Diseases; Disease-vectors; Genetic-factors; Antibody-response; Morbidity-rates; Mortality-rates; Autoimmunity; Malignancy; Immune-system; Immune-reaction; Author Keywords: GM allotypes; humoral immunity; human cytomegalovirus; glycoprotein B; candidate genes
Contact
Dr. Janardan P. Pandey, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, SC 29425
CODEN
JIDIAQ
Publication Date
20141201
Document Type
Journal Article
Email Address
pandeyj@musc.edu
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M072014
Issue of Publication
11
ISSN
0022-1899
NIOSH Division
DART; DSHEFS
Priority Area
Research Tools and Approaches: Exposure Assessment Methods; Healthcare and Social Assistance; Manufacturing; Services
Source Name
The Journal of Infectious Diseases
State
SC; OH
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