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The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments.

Authors
Souter-I; Smith-KW; Dimitriadis-I; Ehrlich-S; Williams-PL; Calafat-AM; Hauser-R
Source
Reprod Toxicol 2013 Dec; 42:224-231
NIOSHTIC No.
20044683
Abstract
In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (+/-GSD) of 1.6+/-2.0, 1.7+/-2.1, and 1.5+/-1.8 g/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
Keywords
Humans; Women; Reproductive-system; Fertility; Medical-treatment; Urinalysis; Mathematical-models; Hormone-activity; Hormones; Phenols; Reproductive-effects; Toxic-materials; Toxicology; Steroids; Estrogenic-hormones; Statistical-analysis; Endocrine-function; Author Keywords: Bisphenol-A; Antral follicle count; Day-3 follicle stimulating hormone; Ovarian volume; Ovarian reserve
Contact
Irene Souter, Massachusetts General Hospital Fertility Center,Yawkey 10-A, 55 Fruit Street, Boston, MA 02114, USA
CODEN
REPTED
CAS No.
80-05-7
Publication Date
20131201
Document Type
Journal Article
Email Address
isouter@partners.org
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008578
ISSN
0890-6238
Source Name
Reproductive Toxicology
State
MA; GA
Performing Organization
Harvard University, School of Public Health, Boston, Massachusetts
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