The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments.
Souter-I; Smith-KW; Dimitriadis-I; Ehrlich-S; Williams-PL; Calafat-AM; Hauser-R
Reprod Toxicol 2013 Dec; 42:224-231
In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (+/-GSD) of 1.6+/-2.0, 1.7+/-2.1, and 1.5+/-1.8 µg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
Humans; Women; Reproductive-system; Fertility; Medical-treatment; Urinalysis; Mathematical-models; Hormone-activity; Hormones; Phenols; Reproductive-effects; Toxic-materials; Toxicology; Steroids; Estrogenic-hormones; Statistical-analysis; Endocrine-function;
Author Keywords: Bisphenol-A; Antral follicle count; Day-3 follicle stimulating hormone; Ovarian volume; Ovarian reserve
Irene Souter, Massachusetts General Hospital Fertility Center,Yawkey 10-A, 55 Fruit Street, Boston, MA 02114, USA
Harvard University, School of Public Health, Boston, Massachusetts