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Inverse association between toenail arsenic and body mass index in a population of welders.

Authors
Grashow-R; Zhang-J; Fang-SC; Weisskopf-MG; Christiani-DC; Kile-ML; Cavallari-JM
Source
Environ Res 2014 May; 131:131-133
NIOSHTIC No.
20044633
Abstract
Recent data show that arsenic may play a role in obesity-related diseases. However, urinary arsenic studies report an inverse association between arsenic level and body mass index (BMI). We explored whether toenail arsenic, a long-term exposure measure, was associated with BMI in 74 welders with known arsenic exposure. BMI showed significant inverse associations with toenail arsenic (p=0.01), which persisted in models adjusted for demographics, diet and work history. It is unclear whether low arsenic biomarker concentrations in high BMI subjects truly reflect lower exposures, or instead reflect internal or metabolic changes that alter arsenic metabolism and tissue deposition.
Keywords
Arsenic-compounds; Humans; Men; Women; Welding; Welders; Body-weight; Weight-factors; Urinalysis; Exposure-levels; Risk-factors; Models; Demographic-characteristics; Biomarkers; Metabolic-rate; Metabolism; Author Keywords: Arsenic; Toenail; BMI; Welding fume; Metals; Occupational health
Contact
Rachel Grashow, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215
CODEN
ENVRAL
CAS No.
7440-38-2
Publication Date
20140501
Document Type
Journal Article
Email Address
rgrashow@hsph.harvard.edu
Funding Type
Cooperative Agreement; Construction
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U60-OH-009762; M072014
ISSN
0013-9351
Priority Area
Construction
Source Name
Environmental Research
State
MA; OR; CT
Performing Organization
CPWR - The Center for Construction Research and Training, Silver Spring, Maryland
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