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A retrospective cohort mortality study of US phosphate industry workers: an update.

Authors
Yiin-J; Kubale-T; Daniels-R; Dunn-K
Source
Occup Environ Med 2014 Jun; 71(Suppl 1):A73-A74
NIOSHTIC No.
20044609
Abstract
Objectives: To evaluate the mortality experience among all workers (n = 3199) employed at a phosphate fertiliser plant in central Florida beginning 1953 and followed through 2005. Method All-cause, all-cancers, and cause-specific standardised mortality ratios (SMRs) were calculated with the U. S. population as referent. Lung cancer and leukaemia risks were further evaluated using conditional logistic regression. Employment duration was used as an exposure surrogate for dose-response analyses. Results: The mortality due to all causes combined (SMR=1.07, 95% confidence interval (CI)=1.01-1.13, observed deaths n = 1124), lung cancer (SMR=1.25, 95% CI=1.04-1.49, n = 122), leukaemia (SMR=1.76, 95% CI=1.02-2.81, n = 17), and chronic obstructive pulmonary disease (SMR=1.45, 95% CI=1.09-1.89, n = 54) were significantly elevated. All-cancer mortality was elevated (SMR=1.09, 95% CI=0.97-1.22, n = 303) but not statistically significant for the cohort. Doseresponse modelling with adjustments for gender and race did not show statistically significant associations between employment duration (in years) and lung cancer (Odds Ratio (OR) =0.99, 95% CI=0.97-1.02) or leukaemia (OR=1.01, 95% CI=0.96-1.06) mortality. Conclusions: Findings are suggestive of increased lung cancer and leukaemia mortality from exposures encountered in the phosphate fertiliser industry. Increased employment duration, however, did not have significant associations with increased lung cancer or leukaemia mortality.
Keywords
Humans; Men; Women; Workers; Work-environment; Mortality-data; Phosphates; Statistical-analysis; Morbidity-rates; Cancer; Lung-cancer; Pulmonary-system-disorders; Pulmonary-disorders; Diseases; Dose-response; Models; Fertilizers; Fertilizer-industry
CODEN
OEMEEM
Publication Date
20140601
Document Type
Abstract
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M072014
ISSN
1351-0711
NIOSH Division
DSHEFS; OD
Source Name
Occupational and Environmental Medicine
State
OH
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