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Biomarkers of metabolic syndrome predict accelerated decline of lung function in NYC firefighters that were exposed to WTC particulates.

Authors
Naveed-B; Comfort-AL; Ferrier-N; Kasturiarachchi-KJ; Rom-WN; Prezant-DJ; Weiden-MD; Nolan-A
Source
Am J Respir Crit Care Med 2011 May; 183(Meeting Abstracts):A4795
NIOSHTIC No.
20044589
Abstract
RATIONALE: In the first year post 9/11/2001, there was a decline of 439 mL in FEV1 in FDNY rescue workers, stabilizing to a 25 ml/year decline in the subsequent seven years. Airflow obstruction predominated in 1720 individuals who sought a subspecialty pulmonary evaluation for treatment. We noted that the most severely obstructed patients had significant weight gain. This well phenotyped cohort had serum drawn within the five months post 9/11/2001, allowing us to investigate relationships of metabolic syndrome biomarkers and decline in lung function. METHODS: The treatment cohort (N=1720) was stratified by FEV1 into either obstructed, FEV1<76% predicted (Lower limit of normal for this cohort), or normal airflow, FEV1>76%. A pilot analysis assayed 41 patientsf serum drawn 2.88 +/= 0.99 months following 9/11 for 15 biomarkers of metabolic syndrome by Luminex; 10 cases were obstructed and 31 were normal. All patients had normal pre-9/11 lung function. Serum cholesterol and triglycerides were available on 157 patients, 20/157 were obstructed. The subspecialty PFT was used to stratify patients, months post-9/11. Data represented as means +/= SD and significance was assessed based on p
Keywords
Particulates; Particulate-dust; Employee-exposure; Fire-fighters; Emergency-responders; Rescue-workers; Airborne-particles; Airborne-dusts; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Biomarkers; Pulmonary-function; Blood-serum; Airway-obstruction; Metabolic-study; Bioassays; Serum-cholesterol; Pulmonary-function-tests; Weight-measurement; Peptides
Contact
B. Naveed, New York University Division of Pulmonary and Critical Care, New York, NY
CODEN
AJCMED
Publication Date
20110501
Document Type
Abstract
Email Address
naveeb01@nyumc.org
Funding Type
Cooperative Agreement
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine
State
NY
Performing Organization
New York City Fire Department
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