Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.

Authors
Kagan-VE; Kaprolov-AA; St. Croix-CM; Watkins-SC; Kisin-ER; Kotchey-GP; Balasubramanian-K; Vlasova-II; Yu-J; Kim-K; Seo-W; Mallampalli-RK; Star-A; Shvedova-AA
Source
ACS Nano 2014 Jun; 8(6):5610-5621
NIOSHTIC No.
20044541
Abstract
In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/ NO* f peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.
Keywords
Lung; Animals; Laboratory-animals; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-disorders; Exposure-levels; Biochemical-analysis; Cell-cultures; Models; Nanotechnology; Biodegradation; Author Keywords: single-walled carbon nanotubes; peroxynitrite; biodegradation; lung
CODEN
ANCAC3
Publication Date
20140624
Document Type
Journal Article
Email Address
kagan@pitt.edu
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1936-0851
NIOSH Division
HELD
Priority Area
Mining
Source Name
American Chemical Society Nano
State
PA; WV
TOP