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Particle deposition in a cast of human tracheobronchial airways.

Authors
Zhou-Y; Cheng-Y-S
Source
Aerosol Sci Tech 2005 Jun; 39(6):492-500
NIOSHTIC No.
20044485
Abstract
Regional particle deposition efficiency and deposition patterns were studied experimentally in a human airway replica made from an adult cadaver. The replica includes the oral cavity, pharynx, larynx, trachea, and four generations of bronchi. This study reports deposition results in the tracheobronchial (TB) region. Nine different sizes of monodispersed, polystyrene latex fluorescent particles in the size range of 0.93-30 um were delivered into the lung cast with the flow rates of 15, 30, and 60 l min.-1. Deposition in the TB region appeared to increase with the increasing flow rate and particle size. Comparison of deposition data obtained from physical casts showed agreement with results obtained from realistic airway replicas that included the larynx. Deposition data obtained from idealized airway models or replicas showed lower deposition efficiency. We also compared experimental data with theoretical models based on a simplified bend and bifurcation model. A deposition equation derived from these models was used in a lung dosimetry model for inhaled particles, and we demonstrated that there was general agreement with theoretical models. However, the agreement was not consistent over the large range of Stokes number. The deposition efficiency was found as a function of the Stokes number, bifurcation angle, and the diameters of parent and daughter tubes. An empirical model was developed for the particle deposition efficiency in the TB region based on the experimental data. This model, combined with the oral deposition model developed previously, can be used to predict the particle deposition for inertial effects with improved accuracy.
Keywords
Aerosols; Aerosol-particles; Fibrous-dusts; Inhalants; Airborne-fibers; Air-sampling; Exposure-levels; Risk-factors; Asbestos-fibers; Asbestos-dust; Particulates; Analytical-processes; Computer-models; Computer-software; Computers; Models; Air-flow; Lung; Respiratory-irritants; Respiratory-rate
Contact
Yue Zhou, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
CODEN
ASTYDQ
Publication Date
20050601
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
6
ISSN
0278-6826
Source Name
Aerosol Science and Technology
State
NM
Performing Organization
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
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