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Deposition of fiber in a human airway replica.

Authors
Su-WC; Cheng-YS
Source
J Aerosol Sci 2006 Nov; 37(11):1429-1441
NIOSHTIC No.
20044484
Abstract
Fiber is a notorious occupational hazard. Exposures to airborne asbestos fiber in the workplace increase the incidence of lung cancer for asbestos workers. Due to the lack of experimental data, the nature of fiber deposition in the human airway is unclear. In this study, a set of experiments were carried out to investigate the effect of fiber dimension and fiber inertia on the deposition pattern in the human airway replica. The deposition study was conducted by delivering aerosolized carbon fibers into the replica at constant inspiratory flow rates of 15-60 l/min. The results showed that impaction is the dominant deposition mechanism in this study. Most of the high-inertia fibers deposited in the oropharynx and the carina ridges of the bifurcations in tracheobronchial airways. A series of fiber deposition patterns were obtained and the deposition efficiencies were acquired for certain regions in the human airway replica.
Keywords
Aerosols; Aerosol-particles; Fibrous-dusts; Inhalants; Airborne-fibers; Air-sampling; Exposure-levels; Risk-factors; Asbestos-fibers; Asbestos-dust; Particulates; Analytical-processes; Computer-models; Computer-software; Computers; Models; Air-flow; Simulation-methods; Respiratory-irritants; Oral-cavity; Author Keywords: Fiber; Human airway; Deposition fraction
Contact
Wei-Chung Su, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
CODEN
JALSB7
Publication Date
20061101
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
11
ISSN
0021-8502
Source Name
Journal of Aerosol Science
State
NM
Performing Organization
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
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