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Fiber deposition pattern in two human respiratory tract replicas.

Authors
Su-W-C; Cheng-YS
Source
Inhal Toxicol 2006 Oct; 18(10):749-760
NIOSHTIC No.
20044483
Abstract
This study consisted of a series of experiments to investigate the factors that might affect the fiber deposition pattern in the human respiratory tract. Carbon fibers with uniform diameter and polydispersed length were chosen as the test material. Two geometry-defined human respiratory tract replicas encompassing the oral cavity, oropharynx, larynx, trachea, and first few bifurcations of the tracheobronchial airways were used in this research. Deposition studies were conducted by delivering aerosolized carbon fibers into the replicas at constant inspiratory flow rates of 15, 43.5, and 60 L/min. The results showed that impaction is the dominant deposition mechanism for both replicas. Most of the fibers with high momentum deposited in the oral airway (oral cavity to larynx), and fibers with low momentum were found to pass through the entire replica easily. When comparing the results between the two replicas, fiber length, inspiratory flow rate, and the geometry of the oral airway were found to be factors that might affect the fiber deposition pattern in the human respiratory tract.
Keywords
Aerosols; Aerosol-particles; Fibrous-dusts; Inhalants; Airborne-fibers; Air-sampling; Exposure-levels; Risk-factors; Asbestos-fibers; Asbestos-dust; Particulates; Analytical-processes; Computer-models; Computer-software; Computers; Models; Air-flow; Simulation-methods; Respiratory-irritants; Oral-cavity
Contact
Wei-Chung Su, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
CODEN
INHTE5
Publication Date
20061001
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
10
ISSN
0895-8378
Source Name
Inhalation Toxicology
State
NM
Performing Organization
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
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