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Airflow and deposition of nano-particles in a human nasal cavity.

Authors
Zamankhan-P; Ahmadi-G; Wang-Z; Hopke-PK; Cheng-Y-S; Su-WC; Leonard-D
Source
Aerosol Sci Tech 2006 Jun; 40(6):463-476
NIOSHTIC No.
20044482
Abstract
A 3D computational model was developed to study the flow and the transport and deposition of nano-size particle in a realistic human nasal passage. The nasal cavity was constructed from a series of MRI images of coronal sections of a nose of a live human subject. For several breathing rates associated with low or moderate activities, the steady state flows in the nasal passage were simulated numerically. The airflow simulation results were compared with the available experimental data for the nasal passage. Despite the anatomical differences of the human subjects used in the experiments and computer model, the simulation results were in qualitative agreement with the experimental data. Deposition and transport of ultrafine particles (1 to 100 nm) in the nasal cavity for different breathing rates were also simulated using an Eulerian-Lagrangian approach. The simulation results for the nasal capture efficiency were found to be in reasonable agreement with the available experimental data for a number of human subjects given typical anatomical differences. The computational results for the nasal capture efficiency for nano-particles and various breathing rates in the laminar regime were found to correlate well with the ratio of particle diffusivity to the breathing rate especially for the particles smaller than 20 nm. Based on the simulated results, a semi-empirical equation for the capture efficiency of the nasal passage for nano-size particles was fitted in terms of Peclet number.
Keywords
Aerosols; Aerosol-particles; Fibrous-dusts; Inhalants; Airborne-fibers; Air-sampling; Exposure-levels; Risk-factors; Asbestos-fibers; Asbestos-dust; Particulates; Analytical-processes; Computer-models; Computer-software; Computers; Models; Nasal-cavity; Air-flow; Simulation-methods
Contact
Goodarz Ahmadi, Department of Mechanical and Aeronautical Engineering, Potsdam, New York 13699-5725, USA
CODEN
ASTYDQ
Publication Date
20060601
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
6
ISSN
0278-6826
Source Name
Aerosol Science and Technology
State
NM; NY
Performing Organization
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
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