Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters.
Gaughan-DM; Siegel-PD; Hughes-MD; Chang-C-Y; Law-BF; Campbell-CR; Richards-JC; Kales-SF; Chertok-M; Kobzik-L; Nguyen-P-S; O'Donnell-CR; Kiefer-M; Wagner-GR; Christiani-DC
Am J Ind Med 2014 Jul; 57(7):748-756
Objectives: To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters. Methods: We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2a (8-isoprostane) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated. Results: Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity. Conclusions: Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters.
Fire-fighters; Humans; Men; Women; Exposure-levels; Risk-factors; Stress; Cardiopulmonary-function; Cardiopulmonary-system; Questionnaires; Spirometry; Smoke-inhalation; Respiration; Respiratory-rate; Respiratory-function-tests; Respiratory-system-disorders; Biomarkers;
Author Keywords: vascular stiffness; 8-iso-prostaglandin F2a; 8-hydroxy-2'-deoxyguanosine; spirometry; levoglucosan
DeniseM.Gaughan, ScD, Icahn School of Medicine at Mount Sinai, 17 East 102nd Street, D3-132, NewYork , NY 10029-6574
American Journal of Industrial Medicine