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Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring.

Authors
Langlois-PH; Hoyt-AT; Desrosiers-TA; Lupo-PJ; Lawson-CC; Waters-MA; Rocheleau-CM; Shaw-GM; Romitti-PA; Gilboa-SM; Malik-S; The National Birth Defects Prevention Study
Source
Occup Environ Med 2014 Aug; 71(8):529-535
NIOSHTIC No.
20044435
Abstract
Objectives: While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. We sought to extend this literature using interview data combined with detailed exposure assessment. Methods: Data for 1997-2002 were analysed from mothers of infants without major birth defects in the National Birth Defects Prevention Study, a large population-based case-control study in the USA. Maternal telephone interviews yielded information on jobs held in the month before conception through delivery. From 6252 eligible control mothers, 2803 completed the interview, had a job, met other selection criteria, and were included in the analysis. Two industrial hygienists independently assessed occupational exposure to PAHs from the interview and reviewed results with a third to reach consensus. Small for gestational age (SGA) was the only adverse pregnancy outcome with enough exposed cases to yield meaningful results. Logistic regression estimated crude and adjusted ORs. Results: Of the 2803 mothers, 221 (7.9%) had infants who were SGA. Occupational PAH exposure was found for 17 (7.7%) of the mothers with SGA offspring and 102 (4.0%) of the remaining mothers. Almost half the jobs with exposure were related to food preparation and serving. After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to 3.8). Conclusions: Maternal occupational exposure to PAHs was found to be associated with increased risk of SGA offspring.
Keywords
Reproductive-effects; Reproductive-hazards; Pregnancy; Prenatal-exposure; Birth-defects; Humans; Children; Women; Polycyclic-aromatic-hydrocarbons; Hydrocarbons; Occupational-exposure; Employee-exposure; Exposure-assessment; Health-surveys; Case-studies; Food-processing-workers; Food-services; Risk-factors
Contact
Dr. Peter H Langlois, Texas Center for Birth Defects Research and Prevention, Texas Department of State Health Services, PO Box 149347, MC 1964, Austin, TX 78714-9347, USA
CODEN
OEMEEM
Publication Date
20140801
Document Type
Journal Article
Email Address
peter.langlois@dshs.state.tx.us
Funding Type
Contract
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Contract-200-2000-08018; M062014
Issue of Publication
8
ISSN
1351-0711
NIOSH Division
DSHEFS; DART
Priority Area
Manufacturing
Source Name
Occupational and Environmental Medicine
State
TX; NC; OH; CA; IA; GA; AR
Performing Organization
Battelle
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