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Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.

Authors
Matsumoto-RR; Seminerio-MJ; Turner-RC; Robson-MJ; Nguyen-L; Miller-DB; O'Callaghan-JP
Source
Pharmacol Ther 2014 Oct; 144(1):28-40
NIOSHTIC No.
20044420
Abstract
Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.
Keywords
Drugs; Drug-abuse; Body-temperature; Mortality-surveys; Morbidity-rates; Hyperthermia; Toxic-effects; Toxic-dose; Central-nervous-system; Proteins; Author Keywords: Autonomic nervous system; Hyperthermia; Methamphetamine; Reactive oxygen species; Thermoregulation; Toxicity
Contact
Rae R. Matsumoto, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506
CODEN
PHTHDT
Publication Date
20141001
Document Type
Journal Article
Email Address
rmatsumoto@hsc.wvu.edu
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M062014
Issue of Publication
1
ISSN
0163-7258
NIOSH Division
HELD
Source Name
Pharmacology & Therapeutics
State
WV
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