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Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.

Authors
Cummings-KJ; Boylstein-RJ; Stanton-ML; Piacitelli-CA; Edwards-NT; LeBouf-RF; Kreiss-K
Source
Occup Environ Med 2014 Aug; 71(8):549-554
NIOSHTIC No.
20044401
Abstract
Objectives: To better understand respiratory symptoms and lung function in flavouring manufacturing workers. Methods: We offered a questionnaire and lung function testing to the current workforce of a flavouring manufacturing facility that had transitioned away from diacetyl and towards substitutes in recent years. We examined symptoms, spirometric parameters and diffusing capacity measurements by exposure variables, including facility tenure and time spent daily in production areas. We used linear and logistic regression to develop final models adjusted for age and smoking status. Results: A total of 367 (93%) current workers participated. Shortness of breath was twice as common in those with tenure >/= 7 years (OR 2.0, 95% CI 1.1 to 3.6). Other chest symptoms were associated with time spent daily in production. Participants who spent >/= 1 h daily in production areas had twice the odds of any spirometric abnormality (OR 2.3; 95% CI 1.1 to 5.3) and three times the odds of low diffusing capacity (OR 2.8; 95% CI 0.9 to 9.4) than other participants. Mean spirometric parameters were significantly lower in those with tenure >/= 7 years and those who spent >/= 1 h daily in production. Mean diffusing capacity parameters were significantly lower in those with tenure >/= 7 years. Differences in symptoms and lung function could not be explained by age, smoking status or employment at another flavouring plant. Conclusions: Symptoms and lung function findings were consistent with undiagnosed or subclinical obliterative bronchiolitis and associated with workplace exposures. Further efforts to lower exposures to flavouring chemicals, including diacetyl substitutes, are warranted.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Food-additives; Chemical-factory-workers; Chemical-manufacturing-industry; Health-surveys; Questionnaires; Pulmonary-function-tests; Spirometry; Chemical-processing; Mathematical-models; Lung-function; Diffusion-analysis; Employee-exposure; Occupational-exposure; Worker-health; HETA 2012-0012-3192
Contact
Dr Kristin J Cummings, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS 2800, Morgantown, WV 26505, USA
CODEN
OEMEEM
CAS No.
431-03-8
Publication Date
20140801
Document Type
Journal Article
Email Address
kcummings@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M062014
Issue of Publication
8
ISSN
1351-0711
NIOSH Division
DRDS
Source Name
Occupational and Environmental Medicine
State
WV
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