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Health assessment of gasoline and fuel oxygenate vapors: reproductive toxicity assessment.

Authors
Gray-TM; Steup-D; Roberts-LG; O'Callaghan-JP; Hoffman-G; Schreiner-CA; Clark-CR
Source
Regul Toxicol Pharmacol 2014 Nov; 70(2)(Suppl):S48-S57
NIOSHTIC No.
20044380
Abstract
Vapor condensates of baseline gasoline (BGVC), or gasoline-blended with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were evaluated for reproductive toxicity in rats at target concentrations of 2000, 10,000, or 20,000mg/m3, 6h/day, 7days/week. BGVC and G/MTBE were assessed over two generations, the others for one generation. BGVC and G/MTBE F1 offspring were evaluated for neuropathology and changes in regional brain glial fibrillary acidic protein content. No neurotoxicity was observed. Male kidney weight was increased consistent with light hydrocarbon nephropathy. In adult rats, decreased body weight gain and increased liver weight were seen. Spleen weight decreased in adults and pups exposed to G/TBA. No pathological changes to reproductive organs occurred in any study. Decreased food consumption was seen in G/TAME lactating females. Transient decreases in G/TAME offspring weights were observed during lactation. Except for a minor increase in time to mating in G/TBA which did not affect other reproductive parameters, there were no adverse reproductive findings. The NOAEL for reproductive and offspring parameters was 20,000mg/m3 for all vapor condensates except for lower offspring NOAELs of 10,000mg/m3 for G/TBA and 2000mg/m3 for G/TAME.
Keywords
Vapors; Toxic-effects; Toxic-gases; Toxic-vapors; Toxins; Animals; Laboratory-animals; Neuropathy; Proteins; Fuels; Fumes; Author Keywords: Reproductive toxicity; Gasoline vapor condensates; Methyl tert-butyl ether (MTBE); Ethyl tert butyl ether (ETBE); t-Amyl methyl ether (TAME); Diisopropyl ether (DIPE); t-Butyl alcohol (TBA); Ethanol (EtOH); Glial fibrillary acid protein; Fuel oxygenates
Contact
Thomas M. Gray, American Petroleum Institute, 20360 Clover Field Terrace, Potomac Falls, VA 20165
CODEN
RTOPDW
CAS No.
1634-04-4; 637-92-3; 994-05-8; 108-20-3; 75-65-0; 64-17-5
Publication Date
20141101
Document Type
Journal Article
Email Address
tmgray@reagan.com
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M052014
Issue of Publication
2
ISSN
0273-2300
NIOSH Division
HELD
Priority Area
Construction; Manufacturing
Source Name
Regulatory Toxicology and Pharmacology : RTP
State
VA; TX; CA; WV; NJ; PA; OK
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