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Mortality and cancer incidence in ammonium perfluorooctanoate production workers.

Authors
Raleigh-KK; Alexander-BH; Olsen-GW; Ramachandran-G; Morey-SZ; Church-TR; Logan-PW; Scott-LLF; Allen-EM
Source
Occup Environ Med 2014 Jul; 71(7):500-506
NIOSHTIC No.
20044310
Abstract
Objective: To evaluate mortality and cancer incidence in a cohort of ammonium perfluorooctanoate (APFO) exposed workers. Methods: We linked a combined cohort (n=9027) of employees from APFO and non-APFO production facilities in Minnesota to the National Death Index and to cancer registries of Minnesota and Wisconsin. Industrial hygiene data and expert evaluation were used to create a task-based job exposure matrix to estimate APFO exposure. Standardised mortality ratios were estimated using Minnesota population rates. HRs and 95% CIs for time-dependent cumulative APFO exposure were estimated with an extended Cox model. A priori outcomes of interest included cancers of the liver, pancreas, testes, kidney, prostate and breast, and mortality from cardiovascular, cerebrovascular and chronic renal diseases. Results: Mortality rates in the APFO-exposed cohort were at or below the expected, compared with Minnesota. The HR for dying from the cancer and noncancer outcomes of interest did not show an association with APFO exposure. Similarly, there was little evidence that the incident cancers were associated with APFO exposure. Compared to the non-exposed population, modestly elevated, but quite imprecise HRs were observed in the higher-exposure quartiles for bladder cancer (HR=1.66, 95% CI 0.86 to 3.18) and pancreatic cancer (HR=1.36, 95% CI 0.59 to 3.11). No association was observed between APFO exposure and kidney, prostate or breast cancers. Conclusions: This analysis did not support an association between occupational APFO exposure and the evaluated health endpoints, however, the study had limited power to evaluate some conditions of interest.
Keywords
Mortality-rates; Morbidity-rates; Cancer; Chemical-composition; Chemical-properties; Workers; Work-environment; Exposure-levels; Risk-factors; Humans; Men; Women; Models; Cardiovascular-system; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cerebrovascular-system; Cerebrovascular-system-disorders; Epidemiology; Statistical-analysis
Contact
Dr Bruce H Alexander, Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807 Mayo Building, 420 Delaware Street S.E., Minneapolis, MN 55455
CODEN
OEMEEM
CAS No.
12249-26-2; 3825-26-1
Publication Date
20140701
Document Type
Journal Article
Email Address
balex@umn.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008434; M052014
Issue of Publication
7
ISSN
1351-0711
Source Name
Occupational and Environmental Medicine
State
MN
Performing Organization
University of Minnesota Twin Cities
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