Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Cadmium and peripheral arterial disease: gender differences in the 1999-2004 US National Health and Nutrition Examination Survey.

Authors
Tellez-Plaza-M; Navas-Acien-A; Crainiceanu-CM; Sharrett-AR; Guallar-E
Source
Am J Epidemiol 2010 Sep; 172(6):671-681
NIOSHTIC No.
20044304
Abstract
Gender differences in the association of blood and urine cadmium concentrations with peripheral arterial disease (PAD) were evaluated by using data from 6,456 US adults aged >/= 40 years who participated in the 1999-2004 National Health and Nutrition Examination Survey. PAD was defined as an ankle-brachial blood pressure index of <0.9 in at least one leg. For men, the adjusted odds ratios for PAD comparing the highest with the lowest quintiles of blood and urine cadmium concentrations were 1.82 (95% confidence interval (CI): 0.82, 4.05) and 4.90 (95% CI: 1.55, 15.54), respectively, with a progressive dose-response relation and no difference by smoking status. For women, the corresponding odds ratios were 1.19 (95% CI: 0.66, 2.16) and 0.56 (95% CI: 0.18, 1.71), but there was evidence of effect modification by smoking: among women ever smokers, there was a positive, progressive dose-response relation; among women never smokers, there was a U-shaped dose-response relation. Higher blood and urine cadmium levels were associated with increased prevalence of PAD, but women never smokers showed a U-shaped relation with increased prevalence of PAD at very low cadmium levels. These findings add to the concern of increased cadmium exposure as a cardiovascular risk factor in the general population.
Keywords
Epidemiology; Humans; Men; Women; Sex-factors; Workers; Cadmium-compounds; Metal-compounds; Metallic-compounds; Health-surveys; Blood-vessels; Veins; Muscle-physiology; Circulatory-system; Blood-pressure; Urinalysis; Statistical-analysis; Age-groups; Dose-response; Smoking; Cardiovascular-disease; Cardiovascular-function; Risk-factors; Author Keywords: cadmium; health surveys; metals; peripheral vascular diseases; sex characteristics
Contact
Dr. Ana Navas-Acien, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7033B, Baltimore, MD 21205
CODEN
AJEPAS
CAS No.
7440-38-2
Publication Date
20100915
Document Type
Journal Article
Email Address
anavas@jhsph.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
6
ISSN
0002-9262
Source Name
American Journal of Epidemiology
State
MD
Performing Organization
Johns Hopkins University
TOP