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Toenail metal concentration as a biomarker of occupational welding fume exposure.

Authors
Grashow-R; Zhang-J; Fang-SC; Weisskopf-MG; Christiani-DC; Cavallari-JM
Source
J Occup Environ Hyg 2014 Jun; 11(6):397-405
NIOSHTIC No.
20044288
Abstract
In populations exposed to heavy metals, there are few biomarkers that capture intermediate exposure windows. We sought to determine the correlation between toenail metal concentrations and prior 12-month work activity in welders with variable, metal-rich, welding fume exposures. Forty-eight participants, recruited through a local union, provided 69 sets of toenail clippings. Union-supplied and worker-verified personal work histories were used to quantify hours welded and respirator use. Toenail samples were digested and analyzed for lead (Pb), manganese (Mn), cadmium (Cd), nickel (Ni), and arsenic (As) using ICP-MS. Spearman correlation coefficients were used to examine the correlation between toenail metal concentrations. Using mixed models to account for multiple participation times, we divided hours welded into three-month intervals and examined how weld hours correlated with logtransformed toenail Pb, Mn, Cd, Ni, and As concentrations. Highest concentrations were found for Ni, followed by Mn, Pb and As, and Cd. All the metals were significantly correlated with one another (rho range = 0.28-0.51), with the exception of Ni and As (rho = 0.20, p = 0.17). Using mixed models adjusted for age, respirator use, smoking status, and BMI, we found that Mn was associated with weld hours 7-9 months prior to clipping (p = 0.003), Pb was associated with weld hours 10-12 months prior to clipping (p = 0.03) and over the entire year (p = 0.04). Cd was associated with weld hours 10-12 months prior to clipping (p = 0.05), and also with the previous year's total hours welded (p = 0.02). The association between Ni and weld hours 7-9 months prior to clipping approached significance (p = 0.06). Toenail metal concentrations were not associated with the long-term exposure metric, years as a welder. Results suggest Mn, Pb, and Cd may have particular windows of relevant exposure that reflect work activity. In a population with variable exposure, toenails may serve as useful biomarkers for occupational metal fume exposures to Mn, Pb, and Cd during distinct periods over the year prior to sample collection.
Keywords
Welding; Fumes; Exposure-levels; Biomarkers; Risk-factors; Metal-fumes; Metal-compounds; Metallic-fumes; Metallic-compounds; Respiration; Respirators; Respiratory-equipment; Respiratory-protection; Respiratory-protective-equipment; Respiratory-system-disorders; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function; Workers; Humans; Lead-compounds; Manganese-compounds; Cadmium-compounds; Nickel-compounds; Arsenic-compounds; Men; Age-groups; Smoking; Body-weight; Heavy-metals; Author Keywords: Toenail; welding fume; lead; manganese; cadmium; biomarker
Contact
Rachel Grashow, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor,Boston, MA02215
CODEN
JOEHA2
CAS No.
7439-92-1; 7439-96-5; 7440-43-9; 7440-02-0; 7440-38-2
Publication Date
20140313
Document Type
Journal Article
Email Address
rgrashow@hsph.harvard.edu
Funding Type
Cooperative Agreement; Construction
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U60-OH-009762; M052014
Issue of Publication
6
ISSN
1545-9624
Priority Area
Construction
Source Name
Journal of Occupational and Environmental Hygiene
State
MD
Performing Organization
CPWR - The Center for Construction Research and Training, Silver Spring, Maryland
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