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Protein nanoparticles as drug delivery carriers for cancer therapy.

Authors
Lohcharoenkal-W; Wang-L; Chen-YC; Rojanasakul-Y
Source
Biomed Res Int 2014 Mar; 2014:180549
NIOSHTIC No.
20044210
Abstract
Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability.They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy.
Keywords
Nanotechnology; Particulates; Drugs; Microbiology; Therapeutic-agents; Cancer; Medical-treatment; Proteins; Polymers; Organic-solvents
Contact
Yon Rojanasakul, Mary Babb Randolph Cancer Center,West Virginia University, Morgantown,WV 26506
Publication Date
20140320
Document Type
Journal Article
Email Address
yrojan@hsc.wvu.edu
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M052014
ISSN
2314-6133
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
BioMed Research International
State
WV
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