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Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells.

Authors
Magaye-R; Zhou-Q; Bowman-L; Zou-B; Mao-G; Xu-J; Castranova-V; Zhao-J; Ding-M
Source
PLoS One 2014 Apr; 9(4):e92418
NIOSHTIC No.
20044111
Abstract
While numerous studies have described the pathogenic and carcinogenic effects of nickel compounds, little has been done on the biological effects of metallic nickel. Moreover, the carcinogenetic potential of metallic nickel nanoparticles is unknown. Activator protein-1 (AP-1) and nuclear factor-kB (NF-kB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. Mutation of the p53 tumor suppressor gene is considered to be one of the steps leading to the neoplastic state. The present study examines effects of metallic nickel fine and nanoparticles on tumor promoter or suppressor gene expressions as well as on cell transformation in JB6 cells. Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-kB, and a greater decrease of p53 transcription activity than fine particles. Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, cmyc, C-Jun, p65, and p50 in a time-dependent manner. In addition, both metallic nickel nano- and fine particles increased anchorage-independent colony formation in JB6 P+ cells in the soft agar assay. These results imply that metallic nickel fine and nanoparticles are both carcinogenetic in vitro in JB6 cells. Moreover, metallic nickel nanoparticles may exhibit higher carcinogenic potential, which suggests that precautionary measures should be taken in the use of nickel nanoparticles or its compounds in nanomedicine.
Keywords
Nanotechnology; Nickel-compounds; Pathogens; Pathology; Carcinogens; Metal-compounds; Metallic-compounds; Metallic-minerals; Proteins; Tumors; Genes; Neoplastic-agents; Cell-function; Cellular-function; Cell-transformation; Particulates
CODEN
POLNCL
CAS No.
7440-02-0
Publication Date
20140401
Document Type
Journal Article
Email Address
haojinshun@nbu.edu.cn
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M042014
Issue of Publication
4
ISSN
1932-6203
NIOSH Division
HELD
Priority Area
Construction; Manufacturing
Source Name
Public Library of Science One
State
WV
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