Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Effects of glutathione and age on muscle performance during a chronic exposure of stretch-shortening contractions.

Authors
Cutlip-RG; Baker-BA; Hollander-MS; Ensey-JS; Kashon-ML
Source
Med Sci Sports Exerc 2008 May; 40(5)(Suppl 1):S109
NIOSHTIC No.
20044031
Abstract
The effect of glutathione depletion on the ability of skeletal muscle to adapt to a chronic exposure of high-intensity mechanical loading is not known. PURPOSE: Investigate the effects of glutathione depletion (via L-Buthionine Sulfoxamine (BSO)) and aging on the ability to adapt functionally to a chronic stretchshortening contraction (SSC) exposure. METHODS: The left dorsiflexor muscles of young (12 wks age, N = 16) and old (30 mo age, N = 16) vehicle and BSO treated male Fischer 344 x Brown Norway rats were exposed 3x/week for 4.5 weeks to a protocol of 80 maximum SSCs per exposure in vivo. Performance was characterized by isometric performance, negative and positive work, and peak eccentric force and minimum force during the 4.5 week exposure period. RESULTS: The isometric force, peak eccentric force, and negative work were not statistically different between groups before exposure; however, minimum force and positive work were significantly higher in young than old rodents (P < 0.05 respectively). Age negatively affected the ability of the rats to respond to the chronic exposure, irrespective of treatment in all parameters except isometric force. Old rodents exhibited significantly less values of minimum force, peak force, negative work, and positive work (p < 0.05 respectively) at the end of the exposure period than their younger counterparts. CONCLUSIONS: Age negatively affected the dynamic performance measures, but not the isometric performance after a chronic exposure of SSCs. However, glutathione depletion did not affect the response profile of the two age groups during the chronic exposure.
Keywords
Muscles; Muscle-stress; Muscle-physiology; Muscle-tension; Muscle-tissue; Musculoskeletal-system; Animals; Laboratory-animals; Exposure-levels; Physiology; Physiological-effects; Physiological-function; Age-factors; Force
CODEN
MSPEDA
CAS No.
70-18-8
Publication Date
20080501
Document Type
Abstract
Email Address
rgc8@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0195-9131
NIOSH Division
HELD
Source Name
Medicine and Science in Sports and Exercise
State
WV
TOP