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Is organic farming safer to farmers' health? A comparison between organic and traditional farming.

Authors
Costa-C; García-Lestón-J; Costa-S; Coelho-P; Silva-S; Pingarilho-M; Valdiglesias-V; Mattei-F; Dall'Armi-V; Bonassi-S; Laffon-B; Snawder-J; Teixeira-JP
Source
Toxicol Lett 2014 Oct; 230(2):166-176
NIOSHTIC No.
20043910
Abstract
Exposure to pesticides is a major public health concern, because of the widespread distribution of these compounds and their possible long term effects. Recently, organic farming has been introduced as a consumer and environmental friendly agricultural system, although little is known about the effects on workers' health. The aim of this work was to evaluate genetic damage and immunological alterations in workers of both traditional and organic farming. Eighty-five farmers exposed to several pesticides, thirty-six organic farmers and sixty-one controls took part in the study. Biomarkers of exposure (pyrethroids, organophosphates, carbamates, and thioethers in urine and butyrylcholinesterase activity in plasma), early effect (micronuclei in lymphocytes and reticulocytes, T-cell receptor mutation assay, chromosomal aberrations, comet assay and lymphocytes subpopulations) and susceptibility (genetic polymorphisms related to metabolism - EPHX1, GSTM1, GSTT1 and GSTP1 - and DNA repair-XRCC1 and XRCC2) were evaluated. When compared to controls and organic farmers, pesticide farmers presented a significant increase of micronuclei in lymphocytes (frequency ratio, FR=2.80) and reticulocytes (FR=1.89), chromosomal aberrations (FR=2.19), DNA damage assessed by comet assay (mean ratio, MR=1.71), and a significant decrease in the proportion of B lymphocytes (MR=0.88). Results were not consistent for organic farmers when compared to controls, with a 48% increase of micronuclei in lumphocytes frequency (p=0.016) contrasted by the significant decreases of TCR-Mf (p=0.001) and %T (p=0.001). Our data confirm the increased presence of DNA damage in farmers exposed to pesticides, and show as exposure conditions may influence observed effects. These results must be interpreted with caution due to the small size of the sample and the unbalanced distribution of individuals in the three study groups.
Keywords
Agriculture; Agricultural-industry; Agricultural-products; Agricultural-workers; Farmers; Agricultural-chemicals; Agricultural-machinery; Agricultural-processes; Pesticides; Pesticides-and-agricultural-chemicals; Biomarkers; Genotoxic-effects; Genotoxicity; Immunotoxins; Immunologic-disorders; Pyrethroids; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Carbamates; Thioates; Ethers; Bioassays; Gene-mutation; Cell-alteration; Cell-morphology; Chromosome-damage; Lymphocytes; DNA-damage; Author Keywords: Biomarkers; Pesticides; Organic farming; Genotoxicity; Immunotoxicity
Contact
Carla Costa, Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano, 321, 4000-055 Porto, Portugal
CODEN
TOLED5
Publication Date
20141015
Document Type
Journal Article
Email Address
carla.trindade@insa.min-saude.pt
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M032014
Issue of Publication
2
ISSN
0378-4274
NIOSH Division
DART
Source Name
Toxicology Letters
State
OH
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