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Assessing the reproductive health of men with occupational exposures.

Authors
Schrader-SM; Marlow-KL
Source
Asian J Androl 2014 Jan; 16(1):23-30
NIOSHTIC No.
20043692
Abstract
The earliest report linking environmental (occupational) exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane (DBCP) on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. Many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined.
Keywords
Reproduction; Reproductive-system; Reproductive-system-disorders; Humans; Men; Exposure-levels; Risk-factors; Cancer; Toxins; Toxic-effects; Lead-compounds; Demographic-characteristics; Epidemiology; Workers; Work-environment; Endocrinology; Endocrine-function; Endocrine-system; Endocrine-system-disorders; Toxicology; Author Keywords: accessory glands; endocrine; epidemiology; semen; sexual function; sperm; testis; toxicology
CAS No.
96-12-8; 7439-92-1
Publication Date
20140101
Document Type
Journal Article
Email Address
sms4@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M022014
Issue of Publication
1
ISSN
1745-7262
NIOSH Division
DART
Priority Area
Manufacturing
Source Name
Asian Journal of Andrology
State
OH
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