Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Acetylcholinesterase activity and neurodevelopment in boys and girls.

Authors
Suarez-Lopez-JR; Himes-JH; Jacobs-DR Jr.; Alexander-BH; Gunnar-MR
Source
Pediatrics 2013 Dec; 132(6):e1649-1658
NIOSHTIC No.
20043676
Abstract
BACKGROUND: Organophosphate exposures can affect children's neurodevelopment, possibly due to neurotoxicity induced by acetylcholinesterase (AChE) inhibition, and may affect boys more than girls. We tested the hypothesis that lower AChE activity is associated with lower neurobehavioral development among children living in Ecuadorian floricultural communities. METHODS: In 2008, we examined 307 children (age: 4-9 years; 52% male) and quantified AChE activity and neurodevelopment in 5 domains: attention/executive functioning, language, memory/learning, visuospatial processing, and sensorimotor (NEPSY-II test). Associations were adjusted for demographic and socioeconomic characteristics and height-for-age, flower worker cohabitation, and hemoglobin concentration. RESULTS: Mean 6 standard deviation AChE activity was 3.14 6 0.49 U/ mL (similar for both genders). The range of scores among neurodevelopment subtests was 5.9 to 10.7 U (standard deviation: 2.6-4.9 U). Girls had a greater mean attention/executive functioning domain score than boys. In boys only, there were increased odds ratios of low (,9th percentile) neurodevelopment among those in the lowest tertile versus the highest tertile of AChE activity (odds ratios: total neurodevelopment: 5.14 [95% confidence interval (CI): 0.84 to 31.48]; attention/executive functioning domain: 4.55 [95% CI: 1.19 to 17.38], memory/learning domain: 6.03 [95% CI: 1.17 to 31.05]) after adjustment for socioeconomic and demographic factors, height-forage, and hemoglobin. Within these domains, attention, inhibition and long-term memory subtests were most affected. CONCLUSIONS: Low AChE activity was associated with deficits in neurodevelopment, particularly in attention, inhibition, and memory in boys but not in girls. These critical cognitive skills affect learning and academic performance. Added precautions regarding secondary occupational pesticide exposure would be prudent.
Keywords
Humans; Children; Organo-phosphorus-compounds; Neurological-system; Neurotoxicity; Acetylcholinesterase; Demographic-characteristics; Age-groups; Sociological-factors; Insecticides; Pesticides; Pesticides-and-agricultural-chemicals; Agriculture; Statistical-analysis; Behavior; Author Keywords: acetylcholinesterase; AChE; ADD; ADHD; agriculture; agricultural communities; attention; boys; children; Ecuador; floriculture; flower; girls; growth; inhibition; inhibitory control; memory; neurobehavioral development; neurodevelopment; plantation; pesticide
Contact
Jose R. Suarez-Lopez, MPH, MD, PhD, Division of Global Health, Department of Family and Preventive Medicine, University of California-San Diego, 9500 Gilman Dr M/C 0725, La Jolla, CA 92093-07
CODEN
PEDIAU
Publication Date
20131201
Document Type
Journal Article
Email Address
jrsuarez@ucsd.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R36-OH-009402
Issue of Publication
6
ISSN
0031-4005
Source Name
Pediatrics
State
CA; MN
Performing Organization
University of Minnesota Twin Cities
TOP