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Dependence of vascular damage on higher frequency components in the rat-tail model.

Authors
Goenka-S; Peelukhana-SV; Kim-J; Stringer-KF; Banerjee-RK
Source
Ind Health 2013 Jul; 51(4):373-385
NIOSHTIC No.
20043672
Abstract
Hand-Arm Vibration Syndrome (HAVS) is caused by hand-transmitted vibration in industrial workers. Current ISO guidelines (ISO 5349) might underestimate vascular injury associated with range of vibration frequencies near resonance. A rat-tail model was used to investigate the effects of higher frequencies >100 Hz on early vascular damage. 13 Male Sprague-Dawley rats (250 +/- 15 gm) were used. Rat-tails were vibrated at 125 Hz and 250 Hz (49 m/s2) for 1D, 5D and 10D; D=days (4 h/day). Structural damage of the ventral artery was quantified by vacuole count using Toluidine blue staining whereas biochemical changes were assessed by nitrotyrosine (NT) staining. The results were analyzed using one-way repeated measures mixed-model ANOVA at p<0.05 level of significance. The structural damage increased at 125 Hz causing significant number of vacuoles (40.62 +/- 9.8) compared to control group (8.36 +/- 2.49) and reduced at 250 Hz (12.33 +/- 2.98) compared to control group (8.36 +/- 2.49). However, the biochemical alterations (NT-signal) increased significantly for 125 Hz (143.35 +/- 5.8 gray scale value, GSV) and for 250 Hz (155.8 +/- 7.35 GSV) compared to the control group (101.7 +/- 4.18 GSV). Our results demonstrate that vascular damage in the form of structural and bio chemical disruption is significant at 125 Hz and 250 Hz. Hence the current ISO guidelines might underestimate vascular damage at frequencies >100 Hz.
Keywords
Biomechanics; Body-regions; Vibration; Vibration-exposure; Vibration-effects; Hand-injuries; Hand-tools; Biochemical-indicators; Biochemical-tests; Analytical-models; Animal-studies; Animals; Laboratory-animals; Laboratory-testing; Musculoskeletal-system-disorders; Blood-vessels; Vasomotor-system; Membrane-dysfunction; Power-tools; Tools; Oxidative-processes; Tissue-culture; Author Keywords: Hand-arm vibration syndrome; Resonance frequency; Structural damage; Vacuoles; Biochemical alterations; Nitrotyrosine
Contact
Rupak K. Banerjee, School of Dynamic Systems, Mechanical Engineering Program, University of Cincinnati, USA
CODEN
INHEAO
Publication Date
20130701
Document Type
Journal Article
Email Address
Rupak.Banerjee@uc.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008432
Issue of Publication
4
ISSN
0019-8366
Source Name
Industrial Health
State
OH
Performing Organization
University of Cincinnati
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