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Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China.

Authors
Gallagher-LG; Rosenblatt-KA; Ray-RM; Li-W; Gao-DL; Applebaum-KM; Checkoway-H; Thomas-DB
Source
Cancer Causes Control 2013 Jul; 24(7):1305-1314
NIOSHTIC No.
20043622
Abstract
PURPOSE: Hormonal factors may play a role in the development of lung cancer in women. This study examined the relationship between lung cancer and reproductive factors in a large cohort of women, most of whom never smoked (97%). METHODS: A cohort of 267,400 female textile workers in Shanghai, China, enrolled in a trial of breast self-examination provided information on reproductive history, demographical factors, and cigarette smoking at enrollment in 1989-91. The cohort was followed until July of 2000 for incidence of lung cancer; 824 cases were identified. Hazard ratios (HR) and 95% confidence intervals (CI) associated with selected reproductive factors were calculated using Cox proportional hazards modeling, adjusting for smoking, age, and also parity when relevant. RESULTS: Nulliparous women were at increased risk compared to parous women (HR = 1.33, 95% CI 1.00-1.77). Women who had gone through menopause at baseline were at increased risk compared to women of the same age who were still menstruating. Risk was higher in women with a surgical menopause (HR = 1.64, 95% CI 0.96-2.79) than in those with a natural menopause (HR = 1.35, 95% CI 0.84-2.18), and risk was highest in those postmenopausal women with a hysterectomy and bilateral oophorectomy at baseline (HR = 1.39, 95% CI 0.96-2.00), although the risk estimates were not statistically significant. CONCLUSIONS: These results support experimental data that demonstrate a biological role for hormones in lung carcinogenesis.
Keywords
Cancer; Lung-cancer; Reproductive-system; Humans; Women; Textile-workers; Textiles-industry; Hormones; Hormone-activity; Demographic-characteristics; Risk-analysis; Risk-factors; Carcinogenesis; Physiopathology; Estrogenic-hormones; Age-groups; Epidemiology; Smoking; Author Keywords: Parity; Reproductive; Cohort; Lung cancer
Contact
L. G. Gallagher, Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195, USA
CODEN
CCCNEN
Publication Date
20130701
Document Type
Journal Article
Email Address
lgallag@u.washington.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009390
Issue of Publication
7
ISSN
0957-5243
Source Name
Cancer Causes and Control
State
WA; IL; MA
Performing Organization
Boston University Medical Campus
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