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Retrospective cohort study of a microelectronics and business machine facility.

Authors
Silver-SR; Pinkerton-LE; Fleming-DA; Jones-JH; Allee-S; Luo-L; Bertke-SJ
Source
Am J Ind Med 2014 Apr; 57(4):412-424
NIOSHTIC No.
20043592
Abstract
Objectives: We examined health outcomes among 34,494 workers employed at a microelectronics and business machine facility 1969-2001. Methods: Standardized mortality ratio (SMR) and standardized incidence ratios were used to evaluate health outcomes in the cohort and Cox regression modeling to evaluate relations between scores for occupational exposures and outcomes of a priori interest. Results: Just over 17% of the cohort (5,966 people) had died through 2009. All cause, all cancer, and many cause-specific SMRs showed statistically significant deficits. In hourly males, SMRs were significantly elevated for non-Hodgkin's lymphoma and rectal cancer. Salaried males had excess testicular cancer incidence. Pleural cancer and mesothelioma excesses were observed in workers hired before 1969, but no available records substantiate use of asbestos in manufacturing processes. A positive, statistically significant relation was observed between exposure scores for tetrachloroethylene and nervous system diseases. Conclusions: Few significant exposure-outcome relations were observed, but risks from occupational exposures cannot be ruled out due to data limitations and the relative youth of the cohort.
Keywords
Exposure-assessment; Electronic-equipment; Electronics-industry; Computer-equipment; Solvents; Epidemiology; Statistical-analysis; Mathematical-models; Worker-health; Cancer; Cancer-rates; Mortality-data; Mortality-rates; Lymphatic-cancer; Testes; Men; Humans; Pleural-cavity; Mesothelial-cells; Nervous-system-disorders; Machine-shop-workers; Kidney-tumors; Author Keywords: occupation; cancer; chemicals
Contact
Sharon R. Silver, MS, Division of Surveillance, Hazard Assessment and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati, OH 45226
CODEN
AJIMD8
CAS No.
127-18-4
Publication Date
20140401
Document Type
Journal Article
Email Address
ssilver@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0271-3586
NIOSH Division
DSHEFS
Priority Area
Manufacturing
Source Name
American Journal of Industrial Medicine
State
OH
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