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Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.

Authors
Sager-TM; Wolfarth-MW; Andrew-M; Hubbs-A; Friend-S; Chen-T-H; Porter-DW; Wu-N; Yang-F; Hamilton-RF; Holian-A
Source
Nanotoxicology 2014 May; 8(3):317-327
NIOSHTIC No.
20043552
Abstract
The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that were surface functionalised with -COOH (FMWCNT), were instilled into C57BL/6 mice. The mice were then examined for biomarkers of inflammation and injury, as well as examined histologically for development of pulmonary disease as a function of dose and time. Biomarkers for pulmonary inflammation included cytokines, mediators and the presence of inflammatory cells (IL-1b, IL-18, IL-33, cathepsin B and neutrophils) and markers of injury (albumin and lactate dehydrogenase). The results show that surface modification by the addition of the -COOH group to the MWCNT, significantly reduced the bioactivity and pathogenicity. The results of this study also suggest that in vivo pathogenicity of the BMWCNT and FMWCNT correlates with activation of the NLRP3 inflammasome in the lung.
Keywords
Animals; Laboratory-animals; Lung; Pathology; Biomarkers; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Exposure-levels; Injuries; Pathogenicity; Author Keywords: multi-walled carbon nanotube; surface modification; inflammasome activation; fibrosis; pulmonary toxicity
Contact
Tina M. Sager, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505
Publication Date
20140501
Document Type
Journal Article
Email Address
sst2@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M012014
Issue of Publication
3
ISSN
1743-5390
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Nanotoxicology
State
WV; MT
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