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Simple, distance-based measurement for paper analytical devices.

Authors
Cate-DM; Dungchai-W; Cunningham-JC; Volckens-J; Henry-CS
Source
Lab Chip 2013 Jun; 13(12):2397-2404
NIOSHTIC No.
20043529
Abstract
Paper-based analytical devices (PADs) represent a growing class of elegant, yet inexpensive chemical sensor technologies designed for point-of-use applications. Most PADs, however, still utilize some form of instrumentation such as a camera for quantitative detection. We describe here a simple technique to render PAD measurements more quantitative and straightforward using the distance of colour development as a detection motif. The so-called distance-based detection enables PAD chemistries that are more portable and less resource intensive compared to classical approaches that rely on the use of peripheral equipment for quantitative measurement. We demonstrate the utility and broad applicability of this technique with measurements of glucose, nickel, and glutathione using three different detection chemistries: enzymatic reactions, metal complexation, and nanoparticle aggregation, respectively. The results show excellent quantitative agreement with certified standards in complex sample matrices. This work provides the first demonstration of distance-based PAD detection with broad application as a class of new, inexpensive sensor technologies designed for point-of-use applications.
Keywords
Analytical-instruments; Blood-analysis; Nickel-compounds; Nanotechnology; Enzymatic-effects; Analytical-processes; Metabolism; Oximes; Peroxidases; Metal-compounds; Metallic-compounds
Contact
Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, CO 80523
CODEN
LCAHAM
CAS No.
7440-02-0
Publication Date
20130621
Document Type
Journal Article
Email Address
chuck.henry@colostate.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R21-OH-010050; M122013
Issue of Publication
12
ISSN
1473-0197
Source Name
Lab on a Chip
State
CO
Performing Organization
Colorado State University-Fort Collins
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