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High hsCRP is associated with reduced lung function in structural firefighters.

Authors
Gaughan-DM; Christiani-DC; Hughes-MD; Baur-DM; Kobzik-L; Wagner-GR; Kales-SN
Source
Am J Ind Med 2014 Jan; 57(1):31-37
NIOSHTIC No.
20043515
Abstract
Background: To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters. Methods: We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1s (FEV1%-predicted) and forced vital capacity (FVC%-predicted). Results: Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%). Conclusion: hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.
Keywords
Fire-fighters; Lung; Lung-function; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Humans; Men; Questionnaires; Spirometry; Proteins; Biomarkers; Statistical-analysis; Author Keywords: percent predicted forced expiratory volume in 1 s (FEV1%-predicted); percent predicted forced vital capacity (FVC%-predicted); high-sensitivity C-reactive protein (hsCRP)
Contact
Stefanos N. Kales, Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Building 1, Room1407, Harvard School of Public Health, Boston, MA
CODEN
AJIMD8
Publication Date
20140101
Document Type
Journal Article
Email Address
skales@hsph.harvard.edu
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008416; M122013
Issue of Publication
1
ISSN
0271-3586
NIOSH Division
OD
Source Name
American Journal of Industrial Medicine
State
NY; MA
Performing Organization
Harvard School of Public Health
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