High hsCRP is associated with reduced lung function in structural firefighters.
Gaughan-DM; Christiani-DC; Hughes-MD; Baur-DM; Kobzik-L; Wagner-GR; Kales-SN
Am J Ind Med 2014 Jan; 57(1):31-37
Background: To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters. Methods: We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1s (FEV1%-predicted) and forced vital capacity (FVC%-predicted). Results: Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%). Conclusion: hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.
Fire-fighters; Lung; Lung-function; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Humans; Men; Questionnaires; Spirometry; Proteins; Biomarkers; Statistical-analysis;
Author Keywords: percent predicted forced expiratory volume in 1 s (FEV1%-predicted); percent predicted forced vital capacity (FVC%-predicted); high-sensitivity C-reactive protein (hsCRP)
Stefanos N. Kales, Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Building 1, Room1407, Harvard School of Public Health, Boston, MA
American Journal of Industrial Medicine
Harvard School of Public Health