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Work-related spirometric restriction in flavoring manufacturing workers.

Authors
Kreiss-K
Source
Am J Ind Med 2014 Feb; 57(2):129-137
NIOSHTIC No.
20043440
Abstract
Background: Flavoring-exposed workers are at risk for occupational lung disease. Methods: We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1. Results: Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure. Conclusion: Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology.
Keywords
Spirometry; Airway-obstruction; Respiratory-system-disorders; Respiratory-irritants; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-disorders; Food-additives; Food-processing-workers; Food-processing; Food-processing-industry; Exposure-levels; Toxic-effects; Lung-disease; Lung; Lung-function; Lung-irritants; Lung-disorders; Humans; Workers; Worker-health; Author Keywords: flavorings; diacetyl; hydrogen sulfide; spirometry; spirometric restriction; excessive decline; HETA 2008-0155-3131
Contact
Kathleen Kreiss, MD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
AJIMD8
CAS No.
431-03-8; 7783-06-4
Publication Date
20140201
Document Type
Journal Article
Email Address
kkreiss@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M122013
ISSN
0271-3586
NIOSH Division
DRDS
Source Name
American Journal of Industrial Medicine
State
WV
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