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Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions.

Authors
Shvedova-AA; Yanamala-N; Murray-AR; Kisin-ER; Khaliullin-T; Hatfield-MK; Tkach-AV; Krantz-QT; Nash-D; King-C; Ian Gilmour-M; Gavett-SH
Source
J Toxicol Environ Health, A 2013 Aug; 76(15):907-921
NIOSHTIC No.
20043391
Abstract
Over the past decade, soy biodiesel (BD) has become a first alternative energy source that is economically viable and meets requirements of the Clean Air Act. Due to lower mass emissions and reduced hazardous compounds compared to diesel combustion emissions (CE), BD exposure is proposed to produce fewer adverse health effects. However, considering the broad use of BD and its blends in different industries, this assertion needs to be supported and validated by mechanistic and toxicological data. Here, adverse effects were compared in lungs and liver of BALB/cJ mice after inhalation exposure (0, 50, 150, or 500 g/m(3); 4 h/d, 5 d/wk, for 4 wk) to CE from 100% biodiesel (B100) and diesel (D100). Compared to D100, B100 CE produced a significant accumulation of oxidatively modified proteins (carbonyls), an increase in 4-hydroxynonenal (4-HNE), a reduction of protein thiols, a depletion of antioxidant gluthatione (GSH), a dose-related rise in the levels of biomarkers of tissue damage (lactate dehydrogenase, LDH) in lungs, and inflammation (myeloperoxidase, MPO) in both lungs and liver. Significant differences in the levels of inflammatory cytokines interleukin (IL)-6, IL-10, IL-12p70, monocyte chemoattractant protein (MCP)-1, interferon (IFN) y, and tumor necrosis factor (TNF)-a were detected in lungs and liver upon B100 and D100 CE exposures. Overall, the tissue damage, oxidative stress, inflammation, and cytokine response were more pronounced in mice exposed to BD CE. Further studies are required to understand what combustion products in BD CE accelerate oxidative and inflammatory responses.
Keywords
Biomarkers; Toxins; Toxic-gases; Emission-sources; Diesel-emissions; Diesel-exhausts; Petroleum; Animals; Laboratory-animals; Hazards; Exposure-levels; Risk-factors; Health-hazards; Toxicology; Carbonyls; Lung; Lung-disorders; Lung-function
CODEN
JTEHD6
Publication Date
20130801
Document Type
Journal Article
Email Address
ats1@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
M112013
Issue of Publication
15
ISSN
1528-7394
NIOSH Division
HELD
Priority Area
Mining
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV; NC; TN
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