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Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City firefighters: a nested case-control study.

Authors
Kwon-S; Weiden-MD; Echevarria-GC; Comfort-AL; Naveed-B; Prezant-DJ; Rom-WN; Nolan-A
Source
PLoS One 2013 Oct; 8(10):e76099
NIOSHTIC No.
20043390
Abstract
Objective: After 9/11/2001, some Fire Department of New York (FDNY) workers had excessive lung function decline. We hypothesized that early serum matrix metalloproteinases (MMP) expression predicts World Trade Center-Lung Injury (WTCLI) years later. Methods: This is a nested case-control analysis of never-smoking male firefighters with normal pre-exposure Forced Expiratory Volume in one second (FEV1) who had serum drawn up to 155 days post 9/11/2001. Serum MMP-1, 2,3,7,8, 9, 12 and 13 were measured. Cases of WTC-LI (N = 70) were defined as having an FEV1 one standard deviation below the mean (FEV1
Keywords
Medical-monitoring; Respiratory-system-disorders; Emergency-responders; Pulmonary-system-disorders; Lung-disorders; Dust-exposure; Metalloproteins; Men; Fire-fighters; Blood-serum; Blood-samples; Mathematical-models; Biomarkers; Risk-analysis; Risk-factors; Blood-analysis; Blood-sampling
Contact
Anna Nolan, Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, NY, USA
CODEN
POLNCL
Publication Date
20131016
Document Type
Journal Article
Email Address
anna.nolan@med.nyu.edu
Funding Type
Cooperative Agreement
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242; M112013
Issue of Publication
10
ISSN
1932-6203
Source Name
Public Library of Science One
State
NY
Performing Organization
New York City Fire Department
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