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Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations.

Authors
Yucesoy-B; Talzhanov-Y; Johnson-VJ; Wilson-NW; Biagini-RE; Wang-W; Frye-B; Weissman-DN; Germolec-DR; Luster-MI; Barmada-MM
Source
Vaccine 2013 Nov; 31(46):5381-5391
NIOSHTIC No.
20043357
Abstract
The influence of genetic variability within the major histocompatibility complex (MHC) region on variations in immune responses to childhood vaccination was investigated. The study group consisted of 135 healthy infants who had been immunized with hepatitis B (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using Illumina Goldengate MHC panels (Mapping and Exon Centric). At the 1 year post vaccination check-up total, isotypic, andantigen-specific serum antibody levels were measured using multiplex immunoassays. A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p < 0.001). Linkage disequilibrium patterns and functional annotations showed that significant SNPs were strongly correlated with other functional regulatory SNPs. These SNPs were found to regulate the expression of a group of genes involved in antigen processing and presentation including HLA-A, HLA-C, HLA-G, HLA-H, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DOB, and TAP-2. The results suggest that genetic variations within particular MHC genes can influence immune response to common childhood vaccinations, which in turn may influence vaccine efficacy.
Keywords
Vaccines; Genetic-factors; Immune-reaction; Children; Histology; Hepatitis; Antigens; Antibody-response; Bioassays; Nucleotides; Morphology; Immunoglobulins; Genes; Blood-serum; Genetics; Author Keywords: Major histocompatibility complex; Genetic polymorphism; Childhood vaccine Immune response
Contact
Berran Yucesoy, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
CODEN
VACCDE
Publication Date
20131104
Document Type
Journal Article
Email Address
byucesoy@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M112013
Issue of Publication
46
ISSN
0264-410X
NIOSH Division
HELD; DART; DRDS
Priority Area
Healthcare and Social Assistance; Services
Source Name
Vaccine
State
WV; PA; NC; NV; OH
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