Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Evidence of a paradoxical relationship between endotoxin and lung cancer after accounting for left truncation in a study of Chinese female textile workers.

Authors
Applebaum-KM; Ray-RM; Astrakianakis-G; Gao-DL; Thomas-DB; Christiani-DC; LaValley-MP; Li-W; Checkoway-H; Eisen-EA
Source
Occup Environ Med 2013 Oct; 70(10):709-715
NIOSHTIC No.
20043326
Abstract
Introduction: Occupational exposure to endotoxin, found in Gram-negative bacteria in organic material, has been associated predominantly with a reduced risk of lung cancer among workers. An inverse exposure-response gradient among women textile workers in Shanghai, China, has been reported previously. In this case-cohort study, we investigated the influence of left truncation, which can itself induce a downward trend, on the observed association. Methods: Subjects were enrolled between 1989 and 1991 and followed until 1998. The data were left-truncated as all subjects were hired before baseline. An analysis was performed with 3038 subcohort members and 602 cases of incident lung cancer. To evaluate left truncation, we compared lung cancer rates in those hired longer ago with those hired more recently among unexposed subjects. Cox proportional hazards modelling was used to estimate incident rate ratios (IRRs) and 95% CIs. Results: Among those who were never exposed to workplace endotoxin, we compared lung cancer rates in those hired >35 years before enrolment with workers hired 50 years ago. Conclusions: After examination of left truncation bias, an inverse dose-response between endotoxin and lung cancer remained for all subjects except those hired longest ago.
Keywords
Textile-finishing; Textile-mills; Textile-workers; Textiles; Textiles-industry; Racial-factors; Women; Lung-cancer; Lung-disease; Lung-disorders; Lung-cells; Endotoxins; Employee-exposure; Cancer; Respiratory-system-disorders; Pulmonary-system-disorders; Bacteria; Organic-dusts; Risk-analysis; Dose-response; Workplace-studies
Contact
Dr. Katie M. Applebaum, Department of Epidemiology, Boston University School of Public Health, 715 Albany St., T322E, Boston, MA 02118, USA
CODEN
OEMEEM
Publication Date
20131001
Document Type
Journal Article
Email Address
kappleba@bu.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009390; M112013
Issue of Publication
10
ISSN
1351-0711
Source Name
Occupational and Environmental Medicine
State
MA; WA; CA
Performing Organization
Boston University Medical Campus
TOP