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Occupational and genetic risk factors for osteoarthritis: a review.

Authors
Yucesoy-B; Charles-LE; Baker-B; Burchfiel-CM
Source
Work 2015 Feb; 50(2):261-273
NIOSHTIC No.
20043303
Abstract
BACKGROUND: Osteoarthritis (OA) is a multifactorial disease with strong genetic and occupational components. Although published studies have described several risk factors for OA, very few studies have investigated the occupational and genetic factors that contribute to this debilitating condition. OBJECTIVE: To describe occupational and genetic factors that may contribute to the risk of developing (OA). METHODS: A literature search was conducted in PubMed using the search terms osteoarthritis, occupation, work, and genetics. RESULTS: Heavy physical work load was the most common occupational risk factor for OA in several anatomical locations. Other factors include kneeling and regular stair climbing, crawling, bending and whole body vibration, and repetitive movements. Numerous studies have also shown the influence of genetic variability in the pathogenesis of OA. Genetic variants of several groups of genes e.g., cartilage extracellular matrix structural genes and the genes related to bone density have been implicated in disease pathogenesis. CONCLUSION: This review shows that occupational factors were extensively studied in knee OA unlike OA of other anatomical regions. Although genetic association studies performed to date identified a number of risk variants, some of these associations have not been consistently replicated across different studies and populations. Therefore, more research is needed.
Keywords
Osteogenesis; Bone-disorders; Bone-structure; Genetic-factors; Articulation; Skeletal-defects; Skeletal-system; Chronic-degenerative-diseases; Body-regions; Occupational-diseases; Pain-tolerance; Risk-analysis; Physical-capacity; Physical-stress; Biomechanics; Body-mechanics; Repetitive-work; Pathogenesis; Genes; Knee-disorders; Author Keywords: Joint disorders; joint pain; workers; occupation; genetics
Contact
Dr. Berran Yucesoy, CDC/NIOSH, Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, 1095 Willowdale Road, M/S 3014, Morgantown, WV 26505 USA
CODEN
WORKFK
Publication Date
20150201
Document Type
Journal Article
Email Address
yab7@cdc.gov
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M112013
Issue of Publication
2
ISSN
1051-9815
NIOSH Division
HELD
Priority Area
Healthcare and Social Assistance; Services
Source Name
Work
State
WV
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