Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Development of a sampler to estimate regional deposition of aerosol in the human respiratory tract.

Authors
Koehler-KA; Volckens-J
Source
Ann Occup Hyg 2013 Sep; 57(9):1138-1147
NIOSHTIC No.
20043249
Abstract
A multistage sampler was developed and tested to estimate regional deposition of aerosol in the human respiratory system. The motivation for this research is to improve our ability to estimate inhaled aerosol dose. Current methods for aerosol measurement and exposure/risk assessment are based on particle aspiration (e.g. inhalable PM) or on penetration to various regions of the respiratory system (e.g. PM10). The sampler developed here operates at 1 m3 h-1 (16.7 l min-1) of flow and utilizes several substrates, connected in series, to mimic regional particle deposition. Two sets of polyurethane foam substrates are used to mimic particle deposition in the head airways and tracheobronchial regions, respectively. Particle deposition in the alveolar region is mimicked using diffusion screens. These substrates are amenable to trace chemical analyses but not gravimetric analyses, due to water vapor uptake with small changes in relative humidity.
Keywords
Aerosols; Exposure-assessment; Exposure-levels; Exposure-methods; Inhalation-studies; Particle-aerodynamics; Particle-counters; Respiratory-irritants; Respiratory-system-disorders; Samplers; Sampling; Endotoxins; Measurement-equipment; Airway-obstruction; Airway-resistance; Alveolar-cells; Laboratory-testing; Chemical-analysis; Author Keywords: aerosols; endotoxin; exposure assessment
Contact
Kirsten A.Koehler, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
CODEN
AOHYA3
Publication Date
20130923
Document Type
Journal Article
Email Address
kirsten.koehler@colostate.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-009248; Grant-Number-T42-OH-009229; M102013
Issue of Publication
9
ISSN
0003-4878
Source Name
Annals of Occupational Hygiene
State
MD; CO
Performing Organization
Colorado State University - Fort Collins
TOP