Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Nanoparticles as an emerging environmental and occupational hazard.

Authors
Shvedova-AA
Source
Toxicol Lett 2013 Aug; 221(Suppl 1):S6
NIOSHTIC No.
20043231
Abstract
Advancements in nanotechnology and broad applications of nanomaterials raise the issue of their potential adverse health effects. Among different nanomaterials, carbonaceous nanotubes (CNT) including single/multi-walled carbon nanotubes and nanofibers - with their distinctive physico-chemical, electronic and mechanical properties - are emerging as important objects of toxicological studies. However, toxic effects of CNT have not been well characterized, especially with respect to pulmonary and immune outcomes. By employing proteomics and lipidomics analyses, in vivo ESR spin-trapping technology, redox assessments of antioxidant balance, and quantitative morphometry (including collagen) in wild-type and genetically manipulated mice, we were able to reveal the major pathways through which CNT - in doses relevant to potential occupational exposures - exert their toxic effects in the lung/distant organs of exposed animals. Overall, found an unusual and robust inflammatory and fibrogenic response is closely associated with the progression of oxidative stress in the lung. Because realistic exposures to SWCNT are likely to occur in conjunction with other pathogenic influences, e.g., microbial infections, our finding of compromised bacterial clearance in the lungs of CNT-exposed mice are of great practical importance. The talk will also address important issues of comparative respiratory outcomes of CNTs and asbestos, particularly with regards to pulmonary injury and potential carcinogenicity. Finally, the mechanisms of toxicity will be discussed in the context of current regulations of protection and their sufficiency in environmental and occupational settings.
Keywords
Nanotechnology; Chemical-properties; Electronic-components; Mechanical-properties; Toxicology; Toxic-effects; Pulmonary-system; Pulmonary-function; Immune-system; Immune-reaction; Analytical-processes; Exposure-levels; Risk-factors; Animals; Laboratory-animals; Lung; Fibrous-bodies; Asbestos-fibers; Carcinogenicity
CODEN
TOLED5
CAS No.
1332-21-4
Publication Date
20130828
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
M102013
ISSN
0378-4274
NIOSH Division
HELD
Priority Area
Mining
Source Name
Toxicology Letters
State
WV
TOP