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Exposure to carbon nanotubes leads to changes in the cellular biomechanics.

Authors
Dong-C; Kashon-ML; Lowry-D; Dordick-JS; Reynolds-SH; Rojanasakul-Y; Sargent-LM; Dinu-CZ
Source
Adv Healthc Mater 2013 Jul; 2(7):945-951
NIOSHTIC No.
20043104
Abstract
Exposure to carbon nanotubes induces significant changes in cellular biomechanics. Using nanoindentation, it is observed that the exposed cells have significantly higher stiffness when compared to controls, especially at the nuclear region, and significant increases in surface area. Carbon nanotubes (CNTs) are rolled-up cylindrical structures of single (single-walled carbon nanotube- SWCNT) or multiple (multi-walled carbon nanotube- MWCNT) sheets of graphene that have high aspect ratio, high electrical and thermal conductivity, ultra-light weight, and high mechanical strength. Their unique properties provide a tremendous potential for applications in fields as diverse as electronics , aerospace industries, sensors, actuators, or composites. Based on their properties, researchers have also been exploring CNTs potential for biological and biomedical applications as drug delivery systems, substrate for cells growth in tissue regeneration, therapeutic agents, or as vectors for gene transfection. Such broad applications of CNTs have led to an increased production level and thus increased concerns regarding human and environmental exposure. Further, given their applications in the biomedical field, understanding how biological systems interact with this nanomaterial is urgently needed to create safer therapies, and to regulate occupational exposures.
Keywords
Nanotechnology; Cell-function; Cell-biology; Cellular-function; Cellular-reactions; Cell-transformation; Biomechanics; Exposure-levels; Author Keywords: genetic instability; increased stiffness; nanoindentation; nanotubes exposure
Contact
Chenbo Dong, Prof. C. Z. Dinu, Department of Chemical Engineering, West Virginia University, Morgantown WV, 26506
CODEN
AHMDBJ
Publication Date
20130701
Document Type
Journal Article
Email Address
cerasela-zoica.dinu@mail.wvu.edu
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
M082013
Issue of Publication
7
ISSN
2192-2640
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Advanced Healthcare Materials
State
WV; NY
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