Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Cancer incidence in World Trade Center rescue and recovery workers, 2001-2008.

Authors
Solan-S; Wallenstein-S; Shapiro-M; Teitelbaum-SL; Stevenson-L; Kochman-A; Kaplan-J; Dellenbaugh-C; Kahn-A; Biro-FN; Crane-M; Crowley-L; Gabrilove-J; Gonsalves-L; Harrison-D; Herbert-R; Luft-B; Markowitz-SB; Moline-J; Niu-X; Sacks-H; Shukla-G; Udasin-I; Lucchini-RG; Boffetta-P; Landrigan-PJ
Source
Environ Health Perspect 2013 Jun; 121(6):699-704
NIOSHTIC No.
20043100
Abstract
BACKGROUND: World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. OBJECTIVE: The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. METHODS: Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. Standardized incidence ratios (SIRs) were calculated to compare cancers diagnosed in responders to predicted numbers for the general population. Multivariate regression models were used to estimate associations with degree of exposure. RESULTS: A total of 575 cancers were diagnosed in 552 individuals. Increases above registry-based expectations were noted for all cancer sites combined (SIR = 1.15; 95% CI: 1.06, 1.25), thyroid cancer (SIR = 2.39; 95% CI: 1.70, 3.27), prostate cancer (SIR = 1.21; 95% CI: 1.01, 1.44), combined hematopoietic and lymphoid cancers (SIR = 1.36; 95% CI: 1.07, 1.71), and soft tissue cancers (SIR = 2.26; 95% CI: 1.13, 4.05). When restricted to 302 cancers diagnosed = 6 months after enrollment, the SIR for all cancers decreased to 1.06 (95% CI: 0.94, 1.18), but thyroid and prostate cancer diagnoses remained greater than expected. All cancers combined were increased in very highly exposed responders and among those exposed to significant amounts of dust, compared with responders who reported lower levels of exposure. CONCLUSION: Estimates should be interpreted with caution given the short follow-up and long latency period for most cancers, the intensive medical surveillance of this cohort, and the small numbers of cancers at specific sites. However, our findings highlight the need for continued follow-up and surveillance of WTC responders.
Keywords
Epidemiology; Emergency-response; Emergency-responders; Rescue-workers; Hazardous-materials; Environmental-contamination; Airborne-dusts; Airborne-particles; Cancer; Cancer-rates; Carcinogens; Health-programs; Clinical-diagnosis; Medical-monitoring; Mathematical-models; Analytical-models; Prostate-cancer; Thyroid-gland-disorders; Surveillance-programs; Dust-exposure; Author Keywords: cancer; cancer incidence; cancer registry; epidemiology; September 11th; World Trade Center; WTC Health Program
Contact
S. Solan, World Trade Center Health Program Data Center, Icahn School of Medicine at Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1057, New York, NY 10029 USA
CODEN
EVHPAZ
Publication Date
20130601
Document Type
Journal Article
Email Address
samara.solan@mssm.edu
Funding Type
Cooperative Agreement
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U10-OH-008232; Contract-200-2011-41815; M082013
Issue of Publication
6
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
NY; CT; NJ
Performing Organization
Mount Sinai School of Medicine - New York
TOP