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Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters.

Authors
Cho-SJ; Nolan-A; Echevarria-GC; Kwon-S; Naveed-B; Schenck-E; Tsukiji-J; Prezant-DJ; Rom-WN; Weiden-MD
Source
J Clin Immunol 2013 Aug; 33(6):1134-1142
NIOSHTIC No.
20043098
Abstract
PURPOSE: World Trade Center (WTC) exposure caused airflow obstruction years after exposure. Chitinases and IgE are innate and humoral mediators of obstructive airway disease. We investigated if serum expression of chitinases and IgE early after WTC exposure predicts subsequent obstruction. METHODS: With a nested case-control design, 251 FDNY personnel had chitotriosidase, YKL-40 and IgE measured in serum drawn within months of 9/11/2001. The main outcome was subsequent Forced Expiratory Volume after 1 second/Forced Vital Capacity (FEV1/FVC) less than the lower limit of normal (LLN). Cases (N=125) had abnormal FEV1/FVC whereas controls had normal FEV1/FVC (N=126). In a secondary analysis, resistant cases (N=66) had FEV1 (>/=107 %) one standard deviation above the mean. Logistic regression adjusted for age, BMI, exposure intensity and post-exposure FEV1/FVC modeled the association between early biomarkers and later lung function. RESULTS: Cases and Controls initially lost lung function. Controls recovered to pre-9/11 FEV1 and FVC while cases continue to decline. Cases expressed lower serum chitotriosidase and higher IgE levels. Increase in IgE increased the odds of airflow obstruction and decreased the odds of above average FEV1. Alternately, increasing chitotriosidase decreased the odds of abnormal FEV1/FVC and increased the odds of FEV1 >/=107 %. Serum YKL-40 was not associated with FEV1/FVC or FEV1 in this cohort. CONCLUSIONS: Increased serum chitotriosidase reduces the odds of developing obstruction after WTC-particulate matter exposure and is associated with recovery of lung function. Alternately, elevated IgE is a risk factor for airflow obstruction and progressive lung function decline.
Keywords
Emergency-response; Emergency-responders; Fire-fighters; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-function; Pulmonary-function-tests; Lung-disorders; Lung-function; Biomarkers; Airway-obstruction; Airborne-dusts; Airborne-particles; Particulate-dust; Particulates; Immunoglobulins; Serology; Risk-factors; Author Keywords: Chitotriosidase; immunoglobulin E; WTC particulate matter; pulmonary function testing
Contact
M. D. Weiden, Medicine and Environmental Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
Publication Date
20130801
Document Type
Journal Article
Email Address
michael.weiden@med.nyu.edu
Funding Type
Cooperative Agreement
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242; M082013
Issue of Publication
6
ISSN
0271-9142
Source Name
Journal of Clinical Immunology
State
NY
Performing Organization
New York City Fire Department
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