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Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles.

Authors
Roberts-JR; McKinney-W; Kan-H; Krajnak-K; Frazer-DG; Thomas-TA; Waugh-S; Kenyon-A; MacCuspie-RI; Hackley-VA; Castranova-V
Source
J Toxicol Environ Health, A 2013 Apr; 76(11):651-668
NIOSHTIC No.
20043085
Abstract
Exposure to wet aerosols generated during use of spray products containing silver (Ag) has not been evaluated. The goal was to assess the potential for cardiopulmonary toxicity following an acute inhalation of wet silver colloid. Rats were exposed by inhalation to a low concentration (100 g/m(3)) using an undiluted commercial antimicrobial product (20 mg/L total silver; approximately 33 nm mean aerodynamic diameter [MAD]) or to a higher concentration (1000 g/m(3)) using a suspension (200 mg/L total silver; approximately 39 nm MAD) synthesized to possess a similar size distribution of Ag nanoparticles for 5 h. Estimated lung burdens from deposition models were 0, 1.4, or 14 g Ag/rat after exposure to control aerosol, low, and high doses, respectively. At 1 and 7 d postexposure, the following parameters were monitored: pulmonary inflammation, lung cell toxicity, alveolar air/blood barrier damage, alveolar macrophage activity, blood cell differentials, responsiveness of tail artery to vasoconstrictor or vasodilatory agents, and heart rate and blood pressure in response to isoproterenol or norepinephrine, respectively. Changes in pulmonary or cardiovascular parameters were absent or nonsignificant at 1 or 7 d postexposure with the exceptions of increased blood monocytes 1 d after high-dose Ag exposure and decreased dilation of tail artery after stimulation, as well as elevated heart rate in response to isoproterenol 1 d after low-dose Ag exposure, possibly due to bioavailable ionic Ag in the commercial product. In summary, short-term inhalation of nano-Ag did not produce apparent marked acute toxicity in this animal model.
Keywords
Nanotechnology; Silver-compounds; Inhalation-studies; Aerosol-particles; Aerosols; Laboratory-animals; Laboratory-testing; Exposure-assessment; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Cardiovascular-system-disorders; Cardiopulmonary-function; Cardiopulmonary-system; Cardiopulmonary-system-disorders; Colloids; Toxic-materials; Particle-aerodynamics; Lung-burden; Vasoactive-agents; Cellular-reactions; Heart-rate; Blood-pressure
Contact
Jenny R. Roberts, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd. (M/S 2015), Morgantown, WV 26505, USA
CODEN
JTEHD6
CAS No.
7440-22-4; 7683-59-2
Publication Date
20130401
Document Type
Journal Article
Email Address
jur6@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
M082013
Issue of Publication
11
ISSN
1528-7394
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV; MD
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