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Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects.

Authors
Kielb-C; Lin-S; Herdt-Losavio-M; Bell-E; Chapman-B; Rocheleau-CM; Lawson-C; Waters-M; Stewart-P; Olney-RS; Romitti-PA; Cao-Y; Druschel-C; the National Birth Defects Prevention Study
Source
Int J Hyg Environ Health 2014 Mar; 217(2-3):248-254
NIOSHTIC No.
20043067
Abstract
This population-based U.S. study investigated the association between major musculoskeletal malfor-mations and periconceptional maternal occupational pesticide exposure for a wide range of occupations.We conducted a multi-site case-control analysis using data from the National Birth Defects Preven-tion Study among employed women with due dates from October 1, 1997 through December 31, 2002.Cases included 871 live-born, stillborn, or electively terminated fetuses with isolated craniosynostosis,gastroschisis, diaphragmatic hernia, or transverse limb deficiencies. Controls included 2857 live-borninfants without major malformations. Using self-reported maternal occupational information, an indus-trial hygienist used a job-exposure matrix and expert opinion to evaluate the potential for exposure toinsecticides, herbicides or fungicides for each job held during one month pre-conception through threemonths post-conception. Exposures analyzed included any exposure (yes/no) to pesticides, to insecticidesonly, to both insecticides and herbicides (I + H) and to insecticides, herbicides and fungicides (I + H + F). Weused logistic regression to evaluate the association between exposures and defects, controlling for infantand maternal risk factors. Occupational exposure to I + H + F was associated with gastroschisis amonginfants of women aged 20 years or older (adjusted odds ratio [aOR] = 1.88; 95% confidence interval [CI]:1.16-3.05), but not for women under age 20 (aOR = 0.48; 95% CI: 0.20-1.16). We found no significantassociations for the other defects. Additional research is needed to validate these findings in a separatepopulation.
Keywords
Exposure-levels; Risk-factors; Birth-defects; Pesticides; Pesticides-and-agricultural-chemicals; Humans; Women; Musculoskeletal-system; Musculoskeletal-system-disorders; Etiology; Pregnancy; Prenatal-exposure; Author Keywords: Pesticides; Maternal occupational exposure; Craniosynostosis; Gastroschisis; Diaphragmatic hernia; Transverse limb deficiencies
Contact
Christine Kielb, NYS Department of Health, Corning Tower Room 1203,Empire State Plaza, Albany, NY 12237
CODEN
IJEHFT
Publication Date
20140301
Document Type
Journal Article
Email Address
clk03@health.state.ny.us
Funding Type
Contract
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Contract-200-2000-08010; M082013
Issue of Publication
2-3
ISSN
1438-4639
NIOSH Division
DSHEFS; DART
Priority Area
Manufacturing
Source Name
International Journal of Hygiene and Environmental Health
State
NY; OH; VA; GA; IA
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