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International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 2. Transepidermal water loss and skin hydration.

Authors
du Plessis-J; Stefaniak-AB; Eloff-F; John-SM; Agner-T; Chou-T-C; Nixon-R; Steiner-M; Franken-A; Kudla-I; Holness-L
Source
Skin Res Technol 2013 Aug; 19(3):265-278
NIOSHTIC No.
20043039
Abstract
Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario. Results: Key elements of these guidelines are: (i) to minimize or recognize, to the extent feasible, the influences of relevant endogenous-, exogenous-, environmental- and measurement/instrumentation-related factors; (ii) to measure TEWL with a closed-chamber type instrument; (iii) report results as a difference or percent change (rather than absolute values); and (iv) accurately report any notable deviations from this guidelines. Conclusion: It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results.
Keywords
Exposure-assessment; In-vivo-studies; Health-protection; Health-standards; Skin; Skin-exposure; Physiological-factors; Biological-factors; Skin-protection; Work-environment; Environmental-factors; Data-processing; Water-analysis; Chemical-properties; Author Keywords: skin hydration; transepidermal water loss; skin barrier; stratum corneum; guideline; non-clinical
Contact
Johan du Plessis, North West Univ, Sch Physiol Nutr & Consumer Sci, Private Bag X6001, ZA-2520 Potchefstroom, North West Prov, South Africa
CODEN
SRTEFN
Publication Date
20130801
Document Type
Journal Article
Email Address
Johan.duPlessis@nwu.ac.za
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
M082013
Issue of Publication
3
ISSN
0909-752X
NIOSH Division
DRDS
Priority Area
Manufacturing
Source Name
Skin Research and Technology
State
WV
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