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Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure.

Authors
Dancik-Y; Miller-MA; Jaworska-J; Kasting-GB
Source
Adv Drug Deliv Rev 2013 Feb; 65(2):221-236
NIOSHTIC No.
20043034
Abstract
A comprehensive transient model of chemical penetration through the stratum corneum, viable epidermis and dermis formulated in terms of an Excel(TM) spreadsheet and associated add-in is presented. The model is a one-dimensional homogenization of underlying microscopic transport models for stratum corneum and dermis; viable epidermis is treated as unperfused dermis. The model's salient features are a detailed structural description of the skin layers, a combination of first-principles based transport equations and empirical partition and diffusion coefficients, and the capability of simulating a variety of exposure scenarios. Model predictions are compared with representative in vitro skin permeation data obtained from the literature using as summary parameters total absorption (Q(abs)), maximum flux (J(max)) and skin permeability coefficient (k(p)). The results of this evaluation demonstrate the current state-of-the-art in prediction of transient skin absorption and highlight areas in which further elaborations are needed to obtain satisfactory predictions.
Keywords
Data-processing; Information-systems; Computer-models; Computer-software; Analytical-models; Dermatology; Skin-absorption; Skin-exposure; Metabolic-activation; Metabolic-rate; Metabolism; Humans; Bioactivation; Biological-transport; Pharmaceuticals; Pharmacodynamics; Drug-interaction; Drugs; Chemical-indicators; Microscopy; Simulation-methods; In-vitro-studies; Absorption-rates; Author Keywords: Transdermal drug transport; Stratum corneum (SC); Lipids; Corneocytes; Viable epidermis (VE); Dermis; Mathematical model
Contact
Matthew A. Miller, The University of Cincinnati Academic Health Center, P.O. Box 670004, Cincinnati, OH 45267-0004, USA
CODEN
ADDREP
Publication Date
20130201
Document Type
Journal Article
Email Address
matt.miller@uc.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007529; M082013
Issue of Publication
2
ISSN
0169-409X
Source Name
Advanced Drug Delivery Reviews
State
OH
Performing Organization
University of Cincinnati
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