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Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: a potential preventive agent for coal workers' pneumoconiosis?

Authors
Aladdin-M; Jian-J; Yang-Q; Chen-L-C; Finkelman-RB; Huang-X
Source
Am J Ind Med 2013 Mar; 56(3):292-299
NIOSHTIC No.
20042993
Abstract
Background: Bioavailable iron (BAI) in coal, which may play a key role in causing coal workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals. Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals, possibly explaining the lower CWP prevalence among Western miners. Methods: We measured effects of calcite on BAI in non-cellular and cellular systems involving Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor and markers of epithelial mesenchymal transition (EMT) and inflammation in mice exposed to PA coal. Results: Calcite rapidly eliminated BAI in an aqueous suspension of PA coal. Ferritin induction in human lung epithelial cells exposed to PA coal was effectively eliminated by calcite. Mouse lung tissue markers indicated increased EMT after exposure to PA coal dust, but not after exposure to PA coal plus calcite. Markers of inflammation increased following exposure to PA coal alone, but not following exposure to PA coal plus calcite. Conclusion: Additional research may lead to the use of supplemental calcite in coal mining as a safe and effective way to prevent CWP among Appalachian coal miners.
Keywords
Laboratory-testing; In-vitro-study; In-vivo-study; Disease-prevention; Coal-workers-pneumoconiosis; Coal-dust; Coal-miners; Mining-industry; Coal-mining; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disease; Lung-fibrosis; Iron-compounds; Calcium-compounds; Laboratory-animals; Immune-reaction; Lung-cells; Biomarkers; Author Keywords: iron; calcium; coal workers' pneumoconiosis (CWP); epithelial mesenchymal transition (EMT); fibrosis
Contact
Xi Huang, PhD, New York University School of Medicine, Hospital for Joint Diseases, Room1600, 550 First Avenue, NewYork, NY 10016
CODEN
AJIMD8
CAS No.
471-34-1; 7440-70-2; 7439-89-6
Publication Date
20130301
Document Type
Journal Article
Email Address
xi.huang@nyumc.org
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009771; B20130805; M082013
Issue of Publication
3
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
NY
Performing Organization
New York University School of Medicine - New York
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