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Estimation of a safe level for occupational exposure to vinyl chloride using a benchmark dose method in central China.

Authors
Jiao-J; Feng-N-N; Li-Y; Sun-Y; Yao-W; Wang-W; Zhang-G-H; Sun-S-Y; Tan-H-S; Wang-Q; Zhu-Y; Li-Y; Brandt-Rauf-PW; Xia-Z-L
Source
J Occup Health 2012 Apr; 54(4):263-270
NIOSHTIC No.
20042992
Abstract
OBJECTIVES: The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCM-exposed workers in central China and validate the published results in Shanghai. METHODS: VCM-exposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis-block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure. RESULTS: The MN frequency in the VCM-exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCM-exposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose-response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL(10) was found to be 630.6, 670.2 and 273.7 mg-year for all VCM-exposed workers, males and females, respectively. CONCLUSIONS: These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity.
Keywords
Exposure-levels; Monomers; Chromosome-damage; Workers; Work-environment; Demographic-characteristics; Biomarkers; Humans; Men; Women; Age-factors; Pollutants; Pollution; Toxins; Epidemiology; Analytical-processes; Statistical-analysis; Smoking; Author Keywords: Benchmark dose; Chromosome damage; Micronucleus frequency; Vinyl chloride monomer
Contact
Zhao-lin Xia, Department of Occupational Health and Toxicology, school of Public Health, Fudan University, 138 Yixueyuan road, Shanghai, 200032, China
CAS No.
75-01-4
Publication Date
20120401
Document Type
Journal Article
Email Address
zlxia@shmu.edu.cn
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004192
Issue of Publication
4
ISSN
1341-9145
Source Name
Journal of Occupational Health
State
FL; IL
Performing Organization
University of Illinois
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