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Mortality among workers at Oak Ridge National Laboratory.

Authors
Richardson-DB; Wing-S; Keil-H; Wolf-S
Source
Am J Ind Med 2013 Jul; 56(7):725-732
NIOSHTIC No.
20042979
Abstract
Background: Workers employed at the Oak Ridge National Laboratory (ORNL) were potentially exposed to a range of chemical and physical hazards, many of which are poorly characterized. We compared the observed deaths among workers to expectations based upon US mortality rates. Methods: The cohort included 22,831 workers hired between January 1, 1943 and December 31, 1984. Vital status and cause of death information were ascertained through December 31, 2008. Standardized mortality ratios (SMRs) were computed separately for males and females using US and Tennessee mortality rates; SMRs for men were tabulated separately for monthly-, weekly-, and hourly-paid workers. Results: Hourly-paid males had more deaths due to cancer of the pleura (SMR = 12.09, 95% CI: 4.44, 26.32), cancer of the bladder (SMR = 1.89, 95% CI: 1.26, 2.71), and leukemia (SMR = 1.33, 95% CI: 0.87, 1.93) than expected based on US mortality rates. Female workers also had more deaths than expected from cancer of the bladder (SMR = 2.20, 95% CI: 1.20, 3.69) and leukemia (SMR = 1.64, 95% CI: 1.09, 2.36). The pleural cancer excess has only appeared since the 1980s, approximately 40 years after the start of operations. The bladder cancer excess was larger among workers who also had worked at other Oak Ridge nuclear weapons facilities, while the leukemia excess was among people who had not worked at other DOE facilities. Conclusions: Occupational hazards including asbestos and ionizing radiation may contribute to these excesses.
Keywords
Mortality-data; Mortality-rates; Mortality-surveys; Humans; Employee-exposure; Uranium-compounds; Uranium-ore; Radiation; Radiation-effects; Radiation-exposure; Mathematical-models; Statistical-analysis; Nuclear-hazards; Health-hazards; Laboratories; Laboratory-workers; Men; Women; Cancer; Bladder-cancer; Pleural-cavity; Nuclear-energy; Nuclear-radiation; Nuclear-reactions; Asbestos-dust; Ionizing-radiation; Leukemogenesis; Blood-disorders; Author Keywords: cohort studies; mortality study; occupational diseases
Contact
Dr David B Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
CODEN
AJIMD8
CAS No.
7440-61-1
Publication Date
20130701
Document Type
Journal Article
Email Address
david.richardson@unc.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009471; B20130805
Issue of Publication
7
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
NC
Performing Organization
University of North Carolina, Chapel Hill
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