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Nitrosothiol signaling in anoikis resistance and cancer metastasis.

Authors
Luanpitpong-S; Iyer-AKV; Azad-N; Wang-L; Rojanasakul-Y
Source
For Immunopathol Dis Therap 2012 Apr-Jun; 3(2):141-154
NIOSHTIC No.
20042964
Abstract
Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes. S-nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediated S-nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics.
Keywords
Cellular-function; Nitroso-compounds; Oxides; Molecular-biology; Proteins; Sulfhydryls; Cancer; Cellular-reactions; Disease-prevention; Physiological-response; Pathology; Biological-effects; Cell-damage; Cell-morphology; Author Keywords: nitric oxide; S-nitrosylation; cancer; metastasis; anoikis; invasion
Contact
Yon Rojanasakul, PhD, West Virginia University, Health Sciences Center, P.O. Box 9530, Morgantown, WV 26506
CAS No.
10102-43-9
Publication Date
20120401
Document Type
Journal Article
Email Address
yrojan@hsc.wvu.edu
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
2151-8017
NIOSH Division
HELD
Source Name
Forum on Immunopathological Diseases and Therapeutics
State
VA; WV
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