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The effects of corn and soybean grain dusts on the asthmatic phenotype using a murine model of fungal allergic asthma.

Authors
Sharma-A; Hoselton-SA; Ghosh-S; Schuh-JM
Source
FASEB J 2013 Apr; 27(Meeting Abstracts):648.6
NIOSHTIC No.
20042872
Abstract
Agricultural workers and farming communities are repeatedly exposed to grain dust during harvest, transport, and storage. The recognition that this complex mixture of particulates can trigger acute respiratory distress is not new, but the ways in which it may exacerbate both immediate and long-term outcomes of allergic asthma remain unclear. The objectives of this study are to investigate the impact of repeated grain dust inhalation on the immunologic mechanisms that drive acute and chronic changes in the allergic lung. Using an inhalation model of Aspergillus fumigatus-induced allergic asthma in mouse, we are investigating the effect of repeated exposures to corn and soybean grain dusts (collected from the rafters of commercial grain elevators). Our early data has revealed a prominent, but short-lived, neutrophilia in the airways of na´ve mice subjected to a single, 20-min dust exposure. Continuing, we will compare airway hyperresponsiveness and inflammatory responses after multiple grain dust exposures in na´ve and allergic lungs, as well as the chronic architectural changes that account for much of the morbidity of long-term asthma.
Keywords
Lung-disease; Lung; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function; Pulmonary-disorders; Diseases; Respiratory-system-disorders; Respiration; Agriculture; Agricultural-industry; Agricultural-workers; Farmers; Dusts; Dust-particles; Dust-exposure; Exposure-levels; Risk-factors; Particulate-dust; Particulates; Grain-dusts
CODEN
FAJOEC
Publication Date
20130401
Document Type
Abstract
Funding Type
Cooperative Agreement
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U54-OH-010162; B20130801
ISSN
0892-6638
Priority Area
Agriculture, Forestry and Fishing
Source Name
The FASEB Journal
State
NE; ND
Performing Organization
University of Nebraska
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